The week that I landed my sedentary life ended. I don't think it was necessarily the location (although the Seattliltes' active lifestyles are certainly inspiring) but rather an excuse to grow. This has had the expected knock-on effects, especially in terms of clarity of mind and mood. The important things just work here - I want to deal with 1st world problems (equality, rights, etc.) and not what I used to deal with ("gee there have been many violent crimes in my neighborhood lately").
The bad has been friends. School and college are the best opportunities to make friends and it's tough once you leave. I've been trying meetup.com, but it's slow progress.
If you're on the fence, I say go for it! Put yourself in the mindset of growth and make it happen when you land.