I'd put it in the pile with the rest of the applicants.
The reason being that we where doing mass interviews years ago something like 200 people for 30 positions.
One guy missed his interview time slot by over an hour. Most people would say 'forget it', but for some reason we decided to bring him in at the end of the day.
Not only did he get one of the spots, he was an absolute rock star employee and won numerous corporate awards.
There is no doubt his resume is going to have to impress you, so if it doesn't then he doesn't get an interview.
If his resume is great, and you bring him in for an interview, bring up the lack of a subject, and you might get some interesting insight out of his response.
Really, what do you have to loose? it took you more time to post this to HN than it would have taken you to take a quick look at his CV.