React? There seems to be a consensus forming that it's the best. You can get started really quickly with create-react-app
Even if you don't end up using React itself, alot of libraries are similar in concept. By learning one you can gain the concepts to use many. For example vue.js is really easy to pick up if you already know react.
I'm with you. I used to love web development. These days I find it exhausting unless you limit yourself to a clear set of tools and ignore the rest, at least for a while.