Fermilab used aspirin to detect water leaks in their rings (1979) [pdf]
history.fnal.gov
history.fnal.gov
Regardless, always nice to see people using creative low tech solutions to serious problems.
When hunting for pressurization leaks in the cavernous aircraft, they would throw toilet paper rolls into the air, and look for the direction that the streaming toilet paper was sucked.
Once they threw a toilet paper roll, and it was sucked out of the aircraft so quickly that they didn't spot the "leak" location. So they got a blanket, throw that up, and it was gone too...
https://en.wikipedia.org/wiki/Bleed_air
In this particular case, the "leak" was somewhere in the roof of the aircraft. My friend was laughing about how confused everyone else on the base would have been by seeing a blanket shooting out of the top of the Galaxy.
My uncle engineers water reservoirs and a few months ago he took me on a tour of a 45 MegaLiter concrete subterranean reservoir he had engineered. They were in the process of fixing a leak they discovered - using Kool-aid.
After discovering the leak, they gave a scuba diver a flashlight and a plastic bottle filled with bright red Kool-aid powder. The diver squirted the powder at various places around the reservoir and paid attention to where the red dye went, which found the leaks.
We could conduct a double-blind experiment with a placebo; it would still work. :)
Can't stay for long... I gotta run off to the Z-80 'Brown Bagger'.