It's a matter of monitoring and dosage. You can easily do mass scale sedation with proper monitoring and appropriate patient selection. If your BMI is over 25 or you have OSA, you wouldn't qualify. If you're healthy, fit, and consenting, you could be sedated for a long haul flight and have minimal hangover, perhaps even feeling rested.

Sounds like an industry ready for disruption. If only these damn regulations weren't holding us back.

/s (sort of).