The Financial District of Manhattan (and Midtown) is the only place like that in the U.S., and most people have been to Times Square, so it does a good job conjuring up an emotional reaction in voters.
A lot of people have been to Times Square, but I doubt most United States voters have.
There are ~150 million (134m in the last Presidential election) active American voters. They tilt older and financially better off, which is also the combination that is most likely to have a substantial travel history.
I'd bet on the majority of active US voters - 75m+ - having visited Times Square at least once in their lifetimes.
There are people who never leave their home state, occasionally city/metro are, though I'm not finding a good source on that.
[0]https://www.nytimes.com/2016/03/09/nyregion/record-number-of...