For example, something I encounter every day is Visual Studio and it's helper processes being 32 bit. Because Visual Studio regularly, even on the latest 15.7 preview shits the bed with OutOfMemoryExceptions on our large solution, I'm inclined to rage "why don't they just make it 64 bit? If it could just load more into memory it could get past this indexing hurdle and give me back the UI". But I also understand that if it was that simple they would have done it by now.
Something else, that I understand more, is the LabVIEW RT and FPGA modules only working on 32 bit LabVIEW. I would assume it's related to the compiling and deploying to the 32 bit ARM/x86 RT target.