The trade-off is that of every higher-level VS lower-level anything when it comes to computers:

Higher-level: Dependent on the quality of the "bridge", but generally you will benefit from good-practice security measures, less repetition and more idiomatic code with regard to your language of choice. What you lose is the cost of the bridge and the fact that the bridge itself has to be maintained over time, requiring you to keep up with any API changes.

Lower-level: Generally less approachable for beginners, highly dependent on your capacity to understand all the implications of the choices you will make, will yield more performance if used correctly because the layer between you and the system is smaller but with power comes responsability.