I would recommend using create-react-app for frontend as it sets up all the tooling for you and is production ready. On backend, I would recommend parse-server but I just have a personal affection for its batteries-included approach. You could also just use a simple node/express setup (and/or mount parse-server onto it).
Three major things that might trip you up, and you should read about and practice early:
- Async programming / closures. You can't just call a function on an object in a loop like you can in Python.
- Promises. Figure out how to use these instead of callbacks as soon as you can.
- Prototypical inheritance. I recommend explicitly writing "classes" with the "old style" of YourClass.prototype.method before moving to using the "class" keyword. The "class" keyword is just syntactical sugar on prototypical inheritance so it's a good idea to learn the raw form before the sugared form.
Recommended reading:
- "You Don't Know JS" (https://github.com/getify/You-Dont-Know-JS/blob/master/READM...)
- Source code. Read the source code of as many JS projects as you can find.