If you use conda-build it will do rpath fixups for you. You can also elect to specify that certain dependencies should come from the system. We do this for X11 for the Anaconda Distribution. To use these, in the recipe you list `cdt` (stands for Core Dependency Tree) packages as build dependencies. These packages are repackaged CentOS6 library and devel packages that are never installed on end-users machines, only at build time.