I find Wire(wire.com) to be well designed and usable, especially their mac client. Only issue I have with Wire is having no anonymous sign up and having to rely on a central server to add contacts but the former can be worked around by using a temporary email.

I take issue with having to provide a cell phone number for Signal. I just hope Tox clients get more polished and more usable as every client I've used except toxic has been terribly buggy.