The world's a really complex system, even limited to just the human-systems part of it, and the <50 miles from satellite orbits down to deep-sea drilling that concerns said humans. So in forecasting and speculating on the future, we can't help but project our own fears and hopes - in this case, Thiel is a capitalist/investor who makes a long case for going long on the world economy, with some Biblical quotes and economic history to make it interesting, if not quite convincing. Too many false dichotomies are given - I think it's a good bet the future will not run like a decision tree.
In particular, Thiel wrestles with the fairly old internal contradictions of capitalism that many other thinkers have, some much more in depth. To use one more Biblical reference, the Rapture for globalization is a totally "flat" world of complete freedom for labor and capital (and technology, but presumably not land). Global capitalism runs, shuffles, or stumbles towards that end, with much of its participants heedless of the journey, never mind its destination.
For example, since capitalism's purpose is to accumulate capital for its own sake, it cannot help but be global (early on, slave trade/colonialism), and it cannot help but work against itself in the long run (We'll up profit margins by outsourcing! But wait, then those outsourcers will get richer, and compete to squeeze our own profit margins. Yah, but then they'll outsource too! But wait, the planet is finite...). While it is a very resilient economic system, what might follow it as its contradictions come fully into play is far from clear.
As an aside, here's someone else who's view on the current globalization situation is, I've found, comprehensive and coherent: