In particular, there's a long-accumulating need for a revision of the current dogma on the philosophy of science and its operationalization -- Popper falsificationism, peer review, publication-oriented research, freaking null hypothesis...
Most of our current science has happened before Popper and falsificationism, so there is nothing "essentially true" about the current M.O. of science. And heck, was it falsificationism that brought us vaccines, nuclear energy and computers? Because there's a replication crisis going on in many scientific fields, and particle physics doesn't fit the mold of falsificationism at all.
I'm not coming forward with a solution in an HN comment, but I think we need to stop equating science, the civilizational project, with this specific philosophy of science and social system for organizing science.