I sometimes run into the issue when I'm working on my addons for World of Warcraft. I'll frequently have 2 instances of the game open (~4gb of RAM each) + my editor + whatever else I havn't bothered to close and a ton of chrome tabs. Typcially those extra things are pdf documents, skype, qbittorrent and others I can't recall at the moment. I hit my cap of 16gb RAM pretty consistently.