I saw a talk with Bill Atkinson in which a surprising number of members of the audience claimed to still maintain old hardware just for running Hypercard. Two of the members said they used it to this day to keep their own financial records and/or run POS at their businesses. They also said unequivocally that they weren't programmers.
In a related talk, Atkinson finally came out and said that the idea for Hypercard came to him during an acid trip on a park bench.