Chrome has made significant improvements but has several support issues when navigating the web using assistive technologies (ATs). The Lighthouse feature is good for looking at the accessibility tree and testing though. For your testing efforts, I would focus on IE and Firefox for Windows as that is what most users of ATs will be using. Freedom Scientific, the makers of the JAWS screen reader, suggests using the ESR version of Firefox until some bugs that were introduced last fall are resolved (
http://blog.freedomscientific.com/mozilla-and-freedom-scient...).
This link might be a bit intimidating but you can review the WCAG (Web Content Accessibility Guidelines) content to see what is required for digital accessibility support.
https://www.w3.org/TR/UNDERSTANDING-WCAG20/
If you want more concise Best Practices that map to these standards but are a bit less intimidating, check out the Best Practices on webaccessibility.com.
https://www.webaccessibility.com/best_practices.php