Sure, I'll try... but will probably ramble as I try to put a finger on it.
People matter. Community matters. Relationships matter. Family matters. Helping people who ask for help matters. Small businesses that provide a livelihood in the context of relationships matters. My neighbors, my street condition, my local stores matter. Work and paychecks matter. I guess one way to say it may be things that don't scale matter.
Suffering is normal. Health problems stink. I love when medicine can help people. Most health problems seem to be difficult and medicine sometimes can help, but sometimes can't.
Putting people on the moon matters. Putting a tesla in space doesn't matter. Fortune 500 companies don't matter. The stock market doesn't matter. Fake videos don't matter.
More concretely on the list, taking "Education" as an example: "Scalable solutions in these areas should now be doable thanks to advances in brain science and technologies such as smart home devices, wearables, and mobile."
My immediate thought: No way tech helps more than 3%. Education is "solved", just _very_ difficult to do. Quality families with quality teachers and a good professional support structure (esp for disabilities etc...).
Overall as I looked at ycombinators list, Job's quote comes to mind:
"The problem is I’m older now, I’m 40 years old, and this stuff doesn’t change the world. It really doesn’t.
That’s going to break people’s hearts.
I’m sorry, it’s true. Having children really changes your view on these things. We’re born, we live for a brief instant, and we die. It’s been happening for a long time. Technology is not changing it much – if at all."