The ayahuasca comment makes me think of this:

> In their other research, the authors have also proposed that the serotonin receptors that psychedelics interact with are involved in bringing about “a state of rapid plasticity that is conducive to major change (e.g. in outlook and/or behaviour)—when such change feels necessary (e.g. to aid mental or physical survival). Such a function may be related to humans’ unique capacity for adaptability.”

Quote from https://tripsafe.org/psychedelics-and-connectedness/

So it seems plausible that ayahuasca may be helpful to people in cases like this. (Of course, additional evidence being that psilocybin seems very helpful for people with depression)