The Dvorak Simplified Keyboard
en.wikipedia.org
en.wikipedia.org
Personally I've been using Dvorak for about 3 years and never looked back. I've been using a TypeMatrix keyboard for about that long and I love it. I immediately changed bindings for all the modifiers so I can press them with my thumbs. Here's my "changes.txt" file, which relocates modifiers:
!mod1 = Alt !mod5 = AltGr remove Shift = Shift_L Shift_R remove Control = Control_L Control_R remove mod1 = Alt_L remove mod5 = ISO_Level3_Shift
keysym Next = Shift_L keysym Shift_L = Control_L keysym Shift_R = F32 keysym Control_L = Control_R keysym Prior = Alt_L keysym Alt_L = ISO_Level3_Shift keysym ISO_Level3_Shift = Prior keysym Control_R = Next
add Shift = Shift_L add Control = Control_L Control_R add mod1 = Alt_L add mod5 = ISO_Level3_Shift
This way I press control with my left thumb, shift and alt with my right thumb. Right-shift is remapped to F32, which I then bind to opening parentheses and putting the cursor inside (lisper here). And other misc stuff.