Ask HN: What to use for fast uploads of GB-sized files?

I'm working on a SaaS that will allow users to upload large files (I expect 100MB - 5GB). These files are hard to compress. My users will probably be sitting on very good lines - a gigabit link shared for an institution is typical. I probably don't want to saturate the whole line.

I want to offer fast upload from the browser, so no sFTP/rsync/...

Does anyone have experience in this? I've found resumable.js and tus.io but I couldn't find a good comparison between the two. Then there are some cloud services but with my file sizes I would have to get a second mortgage to pay for those.