[edit: for more information please see: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2010183 ]
> They are stable, nonflammable, moderately toxic gases or liquids which have typically been used as refrigerants and as aerosol propellants.
Edit: why am I getting downvoted for this...?
Freon was invented in 1928, and started mass production a few years later: https://en.wikipedia.org/wiki/Freon
By 1935, 8 million refrigerators had been sold using Freon as their refrigerant: https://www.thoughtco.com/history-of-freon-4072212
His refrigerator comment was some time before 1953: https://plus.maths.org/content/goumldel-and-limits-logic though another source places it around Einstein's death in 1955:[1]
... ahhh, the wiki hole is deep today. :)
[Edited to fix: date of refrigerator comment upper bounded by 1953, not in 1953]. So it's possible he formed the opinion pre-freon, but it seems more likely that it was during the Freon era.
[1] https://books.google.com/books?id=iWy1AAAAQBAJ&pg=PA332&lpg=...