In almost all use cases, there are existing identity, reputation, and legal frameworks that a distributed ledger can depend on. Here's an article I wrote about how most of the time you're better off with a database instead of a blockchain: https://blog.fauna.com/distributed-ledger-without-the-blockc...
There are some cases where existing identity and legal frameworks can't be used, where proof-of-work has some interest. My other problem with proof-of-work is that it can't scale because it always demands that blockchains use more energy than the economic value they are protecting. Here is an analysis of how blockchains aren't immutable: https://www.coindesk.com/blockchain-immutability-myth/