I appear to be the only woman to have ever made the leaderboard (under a different handle). I absolutely get downvotes that I suspect boil down to "shut up, bitch." I have handled it by doing some of the following things:
1. Make sure I am actually being respectful and not an asshole.
2. Walk the fuck away and shut up sometimes.
3. I left for 18 months, to work on my issues and to give someone breathing room that I had friction with whom I felt saw me as personally threatening. I didn't have specific plans to return. I did return in part because posting something one day went better than I expected.
4. Drop it from my end when there is personal friction. This gets vastly better results when I point out someone is behaving poorly towards me. Sometimes they listen. If they don't, the mods (and community as a whole) are much more likely to be sympathetic if I am not putting out the fire with gasoline.
I routinely comment on hot button topics. I have extremely controversial views on some things. But I go out of my way to not piss on people to the best of my ability.
This has included changing my handle after hitting the leaderboard because I concluded that it didn't matter that it wasn't chosen as a feminist handle. What matters is that it is an overwhelmingly male forum and I want no appearance of impropriety as the first woman on the leaderboard. The perception of disrespect became apparent to me and was not something I wanted. So I started over.
I am vastly more satisfied with posting under this handle. Lots of people recognize me as also being Mz. So the difference is not due to being anonymous.
(This comment is not comprehensive. Just a nutshell version of 8.5 years of navigating an overwhelmingly male forum while posting as openly female.)