Comment by minfitzgerald | Hacker News Reader

Comment by minfitzgerald | Hacker News Reader

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Hi Kayhi, thanks. You're right, the evidence, even clinical research that does exist is drowned out in the noise of anecdotal evidence. But there is clinical evidence showing effectiveness in supplementation (see some at http://www.mynutrigene.com/the_science)

We've been frustrated too - because there weren't other supplement companies that were trying to help customers modify dosages, or find out what works for them using a scientific approach. We're not saying we have all of the answers, but that we will discover new findings with you, that can help many more people and fills a gap that the medical system and current off-the-shelf solutions aren't providing.

I also agree with you that elite level athletes typically would use minimal or no supplementation. However, when we interviewed pro athletes, they are also backed by a team of nutritionists, dieticians and coaches that enables them to closely monitor and implement a very strict diet and exercise routine that everyday busy people find impossible to do. We aren't saying everyone needs supplementation, but since 9 out of 10 Americans are deficient according to the National Health and Nutrition Examination Survey (NHANES) under the Center for Disease and Control (CDC), it might be you, and to investigate for yourself. Our customers currently are seeking us for that support as a better alternative than current off-the-shelf solutions.

Can you link me to the reference that states people should use supplements who have a normal diet?

My point was that athletes are using their bodies in the extreme do not require supplements.

Discovering new findings with me is usually fine, but am nervous when it involves my health.

I agree with you, kayhi. This is our health, and we want to make it so that everyone in the world not only top-tier athletes are never deficient.

Sure, here's a CDC report: https://www.cdc.gov/nutritionreport/pdf/Nutrition_Book_compl... as well as this secondary study that summarizes some of the findings https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822995/.

Thanks, but these references are reporting demographic and biochemical indicators. They do not state that people with a normal diet need supplementation.

Summary reference:

"The Nutrition Report has limitations. First, it does not cover information beyond biochemical indicators, such as dietary intake, supplement usage, hematologic measurements, and anthropometric body measurements, which are generally used together with the biomarker information to comprehensively assess nutritional status."

"forfeit insight into the association between variables unique to each individual biomarker"

Hi Kayhi, quickly, what do you define people with normal diet? There is an array of different diet and different health spectrum that doesn't constitute a visit to the doctor or even have the thought of getting a blood panel. As mentioned above, the scientific rigor for each supplement efficacy on some human clinical trials are sometimes over-simplification of findings from very short trials that don't look into more longitudinal studies. And this is just the non-healthy populations. Most clinical trials that do work on healthy populations tend to focus on athletes. We are still looking more studies that focus on "average" populations that aren't necessarily unhealthy and pro athlete population.

In the end, what we are doing is using data to see if controlling for purity in supplementation improves people's definition of health. If we can control parameters (purity, vitamin active form, etc.), can we see those changes quantitatively rather than qualitatively.

Thanks for your inquiry.

Controlling for purity should not be a major problem and should be a baseline for being in the food business. Lifestyle (diet, sleep, stress, alcohol consumption, disease, genetics, etc.) will far outweigh the variable of supplement purity.

I hope you find more studies, but the variables such as those mentioned above will make it very difficult to determine causation.

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