I think it would work against password managers like LastPass which fill in passwords using JS.
In something like 13000 selectors you could easily get the first 2, last 2, and any characters in the middle that are in the password making targeted attacks significantly easier. (This is based on very-very rough napkin math assuming an ~80 character dictionary for upper/lower, numbers, and "symbols" since I didn't want to count)
That's a lot, but it's well within the realm of possibility (it looks like that would end up as about a 1mb css file)