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>The Americas went from 50-100 million people to fewer than 5 million natives because of disease.

Disease which was quite forcefully spread by Europeans as an act of warfare....

https://en.wikipedia.org/wiki/Native_American_disease_and_ep...

As atrocious as it was, it was pretty late. The largest pandemics were probably hundreds of years prior. Some believe the herds of buffalo etc was a sign of an ecosystem in great change, where the change was extinction of societies that previously tended the land.

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