BACE1 deletion in the adult mouse reverses preformed amyloid deposition

Many drugs work on mouse models of a disease but fail to do anything in human trials. Alzheimer's is especially bad about this. And even more specifically this exact pathway, BACE inhibition has had several drugs make it to Phase 3 to slow down Alzheimer's. And not a single damn one has done anything.

Here's an article by an industrial medicinal chemist, who explains the context of the study. tl;dr; It's useless.

http://blogs.sciencemag.org/pipeline/archives/2018/02/15/mor...

So I'm supposing amyloid deposition is Alzheimer's here.