Sure there is. Imagine you had this function:

    int f(void) {
        int x = 1;
        return x * 2;
    }

Then pretend that later you wanted to call f and provide your own value of x for it to transform, but you realise that f doesn't take a parameter, so you go to move the x declaration in f into its parameter list. What you really want to do here is delete the first element of the parameter list, and then move the first expression in its next sibling list (the function body) to the end of it. C syntax doesn't make this easy for editors to do, but the operations can still be thought of in terms of lists.

You get nested expressions whenever you use if or a loop or call a function. C programs might be flatter on average than Lisp programs, but there's still plenty of structural editing you could do. Another example is moving an expression out of or into a loop, without concern for how many lines it takes up, whether it's a function call or a loop or anything.

The difficulty that C syntax creates for editing operations like this isn't C not having the need for Paredit-style editing, it's C not having good support for it.