Not necessarily. Or more precisely, the intuition doesn't have to be in the domain itself.

I've done operational improvement work across supply chain/inventory management, marketing, digital analytics, ecommerce, healthcare revenue cycle management, and call center operations. In almost every case I started with little if any direct domain knowledge. The intuition that was valuable for my work was around systems-oriented thinking applied to business processes and being able to quickly suss out weak or suspiciously opaque areas of the system. The necessary domain knowledge to do so was always picked up from domain experts as I went along.

In fact, taking a naive approach on domain knowledge has always worked in my favor to uncover invalid assumptions that those with domain knowledge just accepted without question.