No, I wouldn’t perform that calculation exactly and explicitly - but I absolutely think about my purchasing decisions in that way. I can give you ballpark estimates of how valuable my time is, how much time it takes and how much it costs to physically go to the grocery store, etc., and give you a ballpark breakeven point. I’d probably pay $20 for a grocery delivery, but I probably wouldn’t pay $50. But I have no idea where the all-in cost of the service actually falls, so I can’t compare. And I do hold other products and services to that same standard - for example, I regularly compare prices between retailers, except for trivial purchases for which comparison shopping isn’t likely to be worth my time.
As for the source of the markups, that really doesn’t matter to me. I care about the total difference in cost between using Instacart and going to the grocery store myself, irrespective of who that additional money goes to.