The complexity of the environment created by and occupied by human experiences is infinite. There are infinite scenarios that humans find themselves in, and there are infinite positive responses to those scenarios. You can take any positive human response to a given scenario and "disprove" the response's positive outcome by changing something about the scenario. But once you do that, you introduce other positive responses that could taken instead.
The principles boil down it into 25 patterns of human behavior that tend to result in success for the individual and his/her greater community. The list is an optimum solution: lowest number of characters for the highest amount of good outcome if followed. When confronting the complexity of existence, a set of guidelines is useful to refer to.
However, anyone that consults a list of principles when their family is in danger is likely not smart enough to comprehend the list anyways, so it does not apply to them.