WireGuard is likely going to be merged into Linux kernel[1]. And it's already supported by latest Systemd 237[2].

If you're comfortable with beta/dev software versions, or using ArchLinux/Debian Sid/other distro with the latest software—there's no reason not to rely on WireGuard today. Otherwise, wait until it arrives at your system, being built into the mainline kernel. Also, I would like it to get audited by independent third-party.

[1] https://www.phoronix.com/scan.php?page=news_item&px=WireGuar...

[2] https://www.phoronix.com/scan.php?page=news_item&px=systemd-...