At the expense of being vastly more difficult for a large number of tasks that a large number of people need to do frequently (specifically, manipulation of physical quantities).
What do I mean? It's very, very easy to take a pound of some substance and reduce down to ounces with a balance: halve, halve, halve & halve again. It's very, very easy to take a gallon of some liquid and reduce it to gills: halve to get 2 pottles, halve each again to get 4 quarts, halve each again to get 8 pints; halve each again to get 16 cups; halve each again to get 32 gills. It's easy to cut a yard into feet (thirds) or a foot into inches (thirds, halves, halves).
But it's very difficult to manipulate physical quantities in the French Revolutionary system: if you have a kilogram of some substance, turning it into decigrams is … a right royal pain, because dividing a weight into tenths with a balance is a chore; you need a set of pre-measured weights to do it. Ditto with a litre; ditto with a metre.
If the French had really wanted to make a difference, they'd have chosen to introduce a different base for arithmetic …
(I certainly agree that it's nice that the whole world has settled on one standard; I just wish that it were a better standard. Much the same as with computing & x86/C/Unix.)