Perhaps it's a bit idiosyncratic, but for my personal surfing, I do some minimal ad-blocking via a local proxy (polipo), but I have it configured to return the default 503 Forbidden response, so sites that have been ad-blocked are marked up with a bunch of ugly error frames, rather than silently rewritten into nicer-looking sites. It keeps sites from loading their terrible video ads, say, while not allowing me to forget that they do have them (which in turn reminds me to be careful when sending such links to people who might not have an ad-blocker installed).
For instance, all these reader-tools like this are utterly worthless for navigating a site, so if the person is at all interested in more they must visit the site. And then you're back to your layout helping things or not.
Advertising revenue: certainly a concern. But no more so than any other adblocker out there. Layout? Not particularly, unless you rely entirely on layout and not on content. In which case, I generally say good riddance.