There's a reason why you would want to run Python and that's the huge, well supported scientific computing libraries it has.
I fully expect plenty of people to do some of the data-crunching in Python, Julia, R, and so on, and bring it into Observable to explore and experiment. And I also expect JavaScript's ecosystem to blossom, especially with WebAssembly & WebGL hitting the mainstream.
I’d expect more python users to bring d3 in that bring python to JavaScript.
And then it occurred to me that CRAN and NPM have a fair bit in common. Both have a package for anything you might imagine, and both have a mix of amazing and less-than-amazing quality.