Wouldn't C# with structs and pointers do the job in many cases? I've been able to get 50-fold increases in speed through heavy optimizations, without switching to another language. Using C or C++ solely for a "speed boost" over C# is not only unnecessary, but it creates more problems than it solves. If you don't know how to optimize within C# (as a C# developer), how are you going to succeed in writing efficient C++ code?
Once you learn the nuances and limitations of making optimizations in C#, then you should start looking into how and when other languages such as C can wisely be used. To name an example, C makes it easier to micromanage assembly instructions (can be done in C# too, but not in a very practical way, and yes I mean assembly and not IL). C also contains more syntax and features which are suitable for bitwise micromanagement, whereas with C# it can be more awkward.