Very different; glucose is metabolized by all cells in the body; fructose only by the liver.

Fructose isn't good for you (or sucrose 50% fructose, high fructose corn syrup 42%-65% fructose etc) https://www.youtube.com/watch?v=dBnniua6-oM

But its sweeter than glucose; and has side-effects like switching of appetite suppression and prolonged exposure does similar damage to the liver as alcohol. Glucose doesn't do that.