Sure, but why would you do that? If you’re running Django, set up your ec2 instance, and run Django. If you’re running lambda, don’t spin up an entire framework in it to run for individual requests. That basically defeats the purpose. You’re not running a tiny little function, as you said. Your running an entire web framework that’s running one tiny function. Instead of doing that, write an actual simple function that does the one thing it needs to do. It will take 200-300 ms to spin up and run the first time, as well as on requests when it scales up, but otherwise will run in 2ms. Keep it really simple and stateless. If some part of that doesn’t work for your use case, then don’t use lambda.

It was not meant to run an entire framework in. If you’re reaching for an entire framework to run a simple function in a lambda, I’d bail on one or the other. Don’t use a framework, or don’t use lambda.