It's not really a concern. U235 is basically radiologically inert, it doesn't become significantly radioactive until after the reactor has been running for a while. The concern with fission reactors in space is for stuff that might return to Earth after it's been in operation long enough to build up other isotopes that are radioactive and subsequently burning up in the atmosphere. For a vehicle that is on a one-way trip to Mars, and where the reactor will be brought online after it's out of Earth's orbit, this isn't a problem.
Edit: even on a round trip it wouldn't be a big deal, the reactor can just be jettisoned before re-entering Earth's gravity well. You just can't have a fission reactor with spent fuel anywhere near Earth orbit. Space reactors in general are pretty interesting, because the design criteria are so different from terrestrial power reactors.