There is a lot of really good advice in there... perhaps almost too much in the sense that it's easy to skip the ones you should pay attention to, and nod along to the ones that reinforce your existing idea of what advice you need. Putting myself in my wife's shoes for a moment, I'm pretty sure she'd say I need to listen to the advice on getting more sleep (I'm typing this at 1am in the UK). In fact, thinking about it, I am going to call it a night now!
I'm a first-time founder, and lucky enough that our company (Overleaf [1]) has been going for five years now. If you haven't had enough of the advice for one evening, you can read my take on it here: https://clutter.errantscience.com/2017/07/31/reflecting-on-t...