Block chain centric use cases don't count since those just reinforce my worst case hypothesis-- that cryptocurrency is a financial MMORPG and a pure value-free bubble.
What's an actual case of an actual team, project, or organization using this stuff to do something... actual?
I'm both a developer and a founder and am very active in tech. I have yet to encounter a single case of someone using a block chain based application in the real world with the exception of the core currency/wire transfer use case of cryptocurrency. We have used it for that ourselves, but as others have noted the appreciation in value is actually harming this use case.
What I see here is heaps of money being raised and a lot of developer time being spent building things without any contact with reality whatsoever. As they say in the military: the first casualty of war is the plan. IMHO there is nearly zero chance that you are building the right thing until you have shipped and iterated a few times, especially with something complex and rather byzantine. The only exception to that might be "scratch your own itch" or "dogs making dog food" projects, but those really aren't exceptions since if you are the customer you can (to some extent and in the early days) short circuit the process by testing on yourself in your own head as you go.
Colony looks like groupware on the block chain. Groupware is a very well known tar pit of death.