High DPI displays are common on PC laptops now, they generally work well in Linux (not so much for legacy apps but you're unlikely to use those).Surprisingly, some Tk applications that I use irregularly actually work with HiDPI with Tk 8.6 (as in, they are scaled up with an integer scaling factor, and are sharp).
Multiple displays with different DPIs also work with Wayland (I have one 4k screen and a LoDPI display 90 degrees rotated). Though, there are some bugs with GNOME 2.26 on Wayland with HiDPI displays that are switched off and on again (e.g. some applications such as GNOME Terminal become blurry, they seem to be rendered at lower DPI and scaled up). I have reported some bugs and the gnome-shell/mutter developers are quite responsive.