Regarding not having "a chance at the global market":
Mark Shuttleworth's Thawte was based in Cape Town, South Africa yet captured almost 50% of the world's SSL certificate market, in the 90s, at a time when South Africa barely had dial-up. In South Africa we have a saying "'n boer maak 'n plan" (a hard-working man makes a plan).
But that was then. Today, I can read Hacker News from my desk in Cape Town, South Africa while looking out at Robben Island or Table Mountain. I can SSH into Amazon EC2. I can PayPal. I can send an email. I can be connected. I can ignore the hype of the Valley when I need to. I can use the distance to think. I can focus on my work and put the hours in. Sometimes, the "disadvantaged" are in fact advantaged.