intercooler should work in any browser that your chosen version of jquery or zepto works in.

If you want to see if a particular browser is compatible with a particular version of intercooler + (jquery || zepto), the unit tests are linked off the release page:

http://intercoolerjs.org/download.html

And you can simply open the the unit test page in question:

http://intercoolerjs.org/release/unit-tests-1.2.1.html?hidep...

This will run all tests for intercooler 1.2.1 using jQuery3 as the underlying library. Be sure to let the window retain focus or a few tests will fail.