You already are bootstrapped by your biology and life experience you do not make decisions in vacuum and there is a good chance that your biology has as much of an impact on your base political views as your nurture.
Hypothetical scenario 2: Suppose that Person A has whatever beliefs in ordinary times, but is put in a stress or otherwise abnormal situation and forced to make whatever decision. Should their decision be their ordinary time logical choice, or their choice under a high amount of stress?
I'm sure I could come up with more scenarios, but the point is, what should be intellectually considered a given person, in circumstances like a simulation where an adversary could heavily muddle the waters.
However as for the latter part of your post anything which is external is irrelevant.
Basically it doesn’t matter if the universe is a simulation a hologram or a marble it has no actual impact on our reality since it’s ohtside of its scope.
If we are being tinkered with it does not detract from our reality in any way it doesn’t change anything since if we are in a simulation then an administrator who modified your code is on the same level as natural law, they are a part of the universe not our peers.