The author is an amazing programmer and has created great tools for developers. I like his 'back to basics' approach here in this article. I like that he's ported his ClojureScript philosophy back to javascript. I'd really like to see the same project done in ClojureScript at some point for comparison!
The premise of the article that the more objects that mutate state locally are used the more complex and more difficult it is to reason about the system becomes is not true. The core principle of data encapsulation in OOP ensures your system will be manageable as it grows. This principle breaks down the complexity into manageable units of self managed simpler pieces of subprograms that are more easily to reason about. And as history has shown this approach did provide capability to programmers to build more complex and manageable systems.