The noticeable career effect for me was (and is) severe job opportunities pool shrinkage. I can't mentally go back to 9-5 @office - that translates to ~95% of jobs off the table.
The idea of getting up early, getting into a car, driving an hour, and sitting at a table with 20 other people surrounding you in one of those open offices that are all the rage today... just kill me now.
This may sound trivial, but being able to take a dump in total privacy and comfort any time of the day is amazing.
I get to be home when my daughter comes back from preschool, make lunch in my own kitchen, and when I clock out for the day I can get right to spending time with my family. Unless I am absolutely in need of work RIGHT NOW I will not take another position that requires I go to an office, even 1 day a week.