We don't really know if it affects ability to fight off germs, but I would assume it does. Fun fact, mix of ibuprofen and tylenol is one of the most effective anti-fever treatments known and by far out of OTC medicines.
Well, I'm a believer now. When it comes to fevers ibuprofen appears to be incredibly effective. I took 800 at the peak of my 102 fever, and within the hour, my temperature was back to normal. Amazing stuff.
Tylenol and ibuprofen are very transparent. There's no obvious effects to remind you that you're on it. Yet multiple scientific studies have shown that the two in combination are just as effective for relieving some kinds of pain as Vicodin.
I can't count the number of times I took Tylenol and 800 of ibuprofen then told everyone at work I was feeling 'better', only to train wreck at the end of the day and feel just as bad as I did that morning
For example, I caught the Coxsackie A virus (“hand, foot, and mouth disease”) from my toddler a few months back, and it got in my gums and made them swell up very uncomfortably for a week. Ibuprofen significantly reduced the inflammation.