https://clojurescript.org/guides/self-hosting
[Edit to correct: the following is no longer entirely valid: see downthread.]
That said, if you want to benefit from the Google Closure optimizations, you currently do need to use the JVM toolchain. IIRC, there's been work on the Google Closure side to run without a JVM, and if that's the case, there may be opportunities in the future to take advantage of this in the ClojureScript toolchain.
Its a ClojureScript compiler built in ClojureScript, which creates NodeJS targets.
Self-Hosted ClojureScript's current downside is that it does not support as many of the ClojureScript libs.
That said, the use of the JVM by ClojureScript is just as a build tool. Don't you already have Java installed on your computer anyways?