I feel like motion and facial expressions will be a much bigger hurdle than raw graphics. The answer to when graphics is not good enough is to get closer and model the physical material more accurately and with more detail. Not necessarily
easy but relatively straightforward. Then it's just optimizations like this article describes (bump mapping doesn't add something that 100x sampling couldn't get, but it does it 100x faster).
But body motion and facial expressions are entirely different. It's not like an optimization problem where you could just throw more computation at it and it could go away, it's just not possible to do perfectly at all. The best we've been able to do is track the motion of real humans and map that to a digital model; we can't generate it from scratch. We don't even have a general and convincing model of how motion should work. With graphics we've been through half a dozen models, and now here we are with PBR+extensions and the result is fantastic.
Believable body and facial expressions are going to be a much bigger hurdle than we've seen with graphics.